TY - CHAP M1 - Book, Section TI - Local Anesthetics A1 - Lehmann, Lance J. A2 - Bajwa, Zahid H. A2 - Wootton, R. Joshua A2 - Warfield, Carol A. PY - 2016 T2 - Principles and Practice of Pain Medicine, 3e AB - Cocaine is a naturally occurring compound. It was the first anesthetic to be discovered and is the only naturally occurring local anesthetic; all others are synthetically derived. Cocaine was introduced in Europe in 1860 after its isolation from coca leaves by German chemist Albert Niemann (1834–1861). Sigmund Freud (1856–1939), the noted Austrian psychoanalyst, was an early proponent of its medicinal uses. He encouraged a physician colleague, Dr. Carl Koller (1857–1944) to experiment with its analgesic properties. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/18 UR - accessanesthesiology.mhmedical.com/content.aspx?aid=1131938266 ER -