It is characterized by recurrent febrile
episodes and erythematosus subcutaneous nodules. Recurrent crops of
symmetrical, tender lesions, 1 to 2 cm in size, may appear in any area.
These nodules rarely suppurate, and spontaneous regression results in a
hyperpigmented atrophic scar that is depressed consequent to subcutaneous
fat necrosis. Weber-Christian disease implies systemic involvement when the
skin lesions are accompanied by arthralgia, myalgias, and abdominal pain. In
severe instances, the inflammation can involve the liver, lungs,
myocardium, spleen, kidneys, and adrenal glands. Xanthogranuloma of the dura
are described.