Gardner Syndrome: An autosomal dominant polyposis disorder
characterized by gastrointestinal adenomas, mostly colon and periampullary cancer.
Other clinical features include soft-tissue lesions, such as sebaceous cysts, fibromas,
leiomyomas, and lipomas, as well as bony lesions, such as multiple osteomas,
exostoses, bone cortical thickening, and dental abnormalities. Genetically
linked to chromosome band 5q21, the adenomatous polyposis coli locus. The
wider spectrum of this disease in comparison to the familial adenomatous
polyposis syndrome may represent a variable penetrance of a common genetic