A rare entity characterized by prenatal and
postnatal overgrowth syndrome. Clinical features include abnormal sacrum, absent
nails/claws, cleft palate most often associated with a cleft of the lower lip, coarse
facial features, macroglossia, coloboma, congenital heart defects (ventricular septal
defect, atrial septal defect), diaphragmatic hernia, hepatomegaly, fusion of
cervical vertebra and limited extension, hydronephrosis, intestinal
malrotation, kidney failure, macrocephaly, and increased risk of embryonal
cancers.