Setleis syndrome is characterized by an aged,
leonine facial appearance, puckered skin around the eyes with periorbital
fullness, and absent or multiple rows of eyelashes. Flat nasal bridge,
bulbous nasal tip, and big lips. Redundant facial soft tissue. These
patients also show characteristic bitemporal skin marks (original
description noted similarity to obstetric 'forceps marks'). An association of
Setleis syndrome has been suggested with imperforate anus, megaureter, bifid scrotum, and
supernumerary nipples has been reported. Initially, these patients were
reported to have normal mental development, but now several reports about
learning difficulties in these patients exist.