Meleda Disease (Mal de Meleda): An extremely rare
disorder characterized by the slow progressive development of palmoplantar
hyperkeratosis. Affected skin may be unusually red and become abnormally
thick. Affected children may exhibit abnormalities of the nails,
hyperhidrosis with unpleasant odor, and/or lichenoid plaques. In addition,
cardiac abnormalities and cardiomegaly have been reported. It is inherited
as an autosomal recessive trait.