Usually a benign metabolic state that produces no clinical
disease. Multiple symptoms have been reported in sarcosinemia such as mental
retardation, growth failure, hepatomegaly, craniostenosis, syndactyly, and
cardiomyopathy. There is large number of patients with a high level of
sarcosine in plasma who do not present any symptoms. Reported association with
clinical symptoms could be as a result of an ascertainment bias.