Charcot-Marie-Tooth Disease: Characterized by muscle weakness and
atrophy, most prominent in the legs and the small muscles of the hands. Patients may
remain active and have a normal life span. Segmental demyelination of peripheral nervous
system including the axons represent classic features of this medical condition. Symptoms
usually begin gradually between middle childhood and age 30 years. The most
incapacitating symptom is “foot drop,” producing a slapping gait and the
associated paresthesias. A decrease in vibration, pain, and thermal
sensation in the hand, foot, and lower part of the leg that manifest
following a distribution pattern of glove and stocking shape. The disease is
slowly progressive, but may arrest spontaneously.