Dental and skin abnormalities (acanthosis nigricans,
truncal hypertrichosis, malpositioned teeth), short stature, coarse facial
features with prognathism, abdominal distension, and phallic enlargement.
Highly insulin-resistant diabetes mellitus. The pineal body is hyperplastic.
Studies of melatonin state show raised melatonin metabolite excretion in the
urine, as might be expected with disordered pineal function.