Children with PHP type Ia present with the
classic Albright hereditary osteodystrophy appearance: small stature with
moderate obesity, mild mental deficiency, rounded face with short neck,
dental aplasia or enamel dysplasia, and subcapsular cataracts. Radiography
shows osteoporosis, short metacarpal bones, and cone-shaped epiphyses.
Cervical vertebral anomalies may be present. Cutaneous or subcutaneous
calcifications. Hypocalcemia, which usually develops in the first years of
life, may lead to tetany, muscle cramps, or seizures. Children with PHP
types Ib and II have a normal physical appearance. PHP type I or II is
treated with vitamin D and oral phosphate binders. Spontaneous amelioration
of hypocalcemia may occur with time.