Hand abnormalities include synostoses of the
carpal bones, radial head subluxation, hypoplasia of the middle phalanges,
and metacarpophalangeal synostoses; short and broad first metacarpal bones,
disturbances in bone modeling of the metacarpal bones and phalanges, and
agenesis of the middle phalanges. Foot abnormalities include synostoses of
the tarsal bones, synostoses of the tarsal and metatarsal bones, agenesis of
the middle and distal phalanges, and disturbance in bone modeling of the
phalanges. Hypoplasia of the alae nasi. Short upper lip. Cubitus valgus,
limited extension of the forearm, and limited hip motion. Variable fusion of
middle ear ossicles. Moderate mental retardation.