Polyglandular endocrine syndrome characterized by the
classic triad of (a) hyperostosis frontalis interna, (b) adipositas, and (c)
virilism and hirsutism. A peculiar, noninflammatory, usually benign
osteopathy with symmetrical thickening of the frontal, parietal, or
occipital bones as a result of deposits on the internal aspects of the
squama frontalis. Other clinical features include menstrual disorders, virilism,
hirsutism, mental disorders, fatigue, somnolence, visual disorders, vertigo,
tinnitus, obesity, polyphagia, polydipsia, polyuria, loss of sense of smell,
decreased glucose tolerance, convulsions, and involvement of the second,
fifth, and seventh cranial nerves with hemiplegia and hemiparesis.