Features involve gastrointestinal (microgastria, asplenia,
splenic hypoplasia, splenogonadal fusion, failure to thrive, gastric ulcer,
malrotation of the gut, congenital megacolon), limbs (absent thumbs, radius,
ulna, arm with single digit at the shoulder), and genitourinary (dysplastic or ectopic
kidney). Torticollis, plagiocephaly, frontal bossing, paresis of ocular
muscles, microphthalmos or anophthalmia, mental retardation,
arrhinencephaly, fused thalami, agenesis of corpus callosum, cranial nerve
anomalies, lissencephaly, absent clavicle, complex heart disease (Atrial septal
defect,
truncus arteriosus), imperforate anus, absent lobe lung, and segmentation
defect can occur.