Genetic disorder characterized by the association of
facial dysmorphism, failure to thrive, and accelerated osseous maturation
and linear growth. Accompanied by severe respiratory problems that are often
fatal during the first year of life, mental retardation, hypotonia, muscle
weakness, and psychomotor retardation. Craniofacial abnormalities include
prominent forehead and eyes, maldevelopment of the epiglottis, and
laryngomalacia.