Lightwood syndrome occurs in neonates and is a
self-limiting condition that rarely requires treatment beyond 18 months.
Males are most commonly affected. Clinical findings include lethargy and
reduced muscle tone, vomiting, constipation, anorexia, failure to thrive,
polyuria, polydipsia, wasting. The clinical and biochemical findings are
reversed by the administration of alkali (up to 25 mEq/kg/day).
Nephrocalcinosis may be a feature, particularly in untreated patients.
Gastroenteritis associated with prolonged dehydration may mimic the