Syndrome characterized by desquamation (severe
generalized seborrheic dermatitis), recurrent local and systemic infection,
severe diarrhea, marked wasting, central nervous system deficiency, and
failure to thrive. It begins as seborrheic eczematoid lesions of the scalp
and face or the gluteal region, eventually spreading to other areas.
Keratitis and corneal ulcers may occur. Caused by complement C5 deficiency
in infancy; rapid onset in second to fourth month of life.