Clinical hyposomatotropism manifested by
proportionate short stature, delayed bone age, limited elbow extension, and
hip degeneration. An important characteristic is the more pronounced decrement in body size than in head size,
resulting in child-like body proportions in adults, small face, prominent
forehead, occasionally blue sclerae, flat nasal bridge, and delayed tooth
development. Patient may have micrognathia, sparse hair, high-pitched voice
(caused by a narrow larynx), delayed menarche in girls, a small-size penis
(which reaches normal adult size) in boys, and normal intelligence. Adult
stature is severely affected (ranging from -4 to -12 standard deviation).
Approximately 50% of infants and children with Laron syndrome present
with overt symptoms of hypoglycemia (especially fasting hypoglycemia),
including seizures. Hip dysplasia, especially avascular necrosis of the
femoral head (Legg-Calvé-Perthes disease) is common.