Sections View Full Chapter Figures Tables Videos Annotate Full Chapter Figures Tables Videos Supplementary Content + At a Glance Download Section PDF Listen ++ Characterized by alopecia, macular degeneration, growth retardation, cleft hand, ectrodactyly syndactyly, and ectodermal dysplasia. + Synonym Download Section PDF Listen ++ Alopecia with Macular Degeneration and Growth Retardation. + Incidence and Genetic Inheritance Download Section PDF Listen ++ One case report exists. Autosomal recessive inheritance most probable. + Clinical Aspects Download Section PDF Listen ++ Repeated loss of scalp and body hair with some regrowth (hypotrichosis) started at the age of 20 years. Ring-shaped (“bull's-eye”) degeneration of the retinal pigmentary epithelium of both eyes with poor visual acuity was noted. Short stature (proportional dwarfism) but otherwise normal musculoskeletal examination. Intelligence was normal. + Anesthetic Considerations Download Section PDF Listen ++ No significant anesthetic considerations specific to this condition. + Other Condition to Be Considered Download Section PDF Listen ++ Ectodermal Dysplasia, Ectrodactyly, and Macular Dystrophy (EEM) Syndrome: Main features are syndactyly and other abnormalities of the fingers and toes, sparse head hair from birth, bilateral macular degeneration, and small widely spaced teeth. + References Download Section PDF Listen ++Kuster W, Majewski F, Hammerstein W: Alopecia, macular degeneration, and growth retardation: A new syndrome? Am J Med Genet 28:477, 1987. [PubMed: 3425621] ++Ohdo S, Hirayama K, Terawaki T: Association of ectodermal dysplasia, ectrodactyly, and macular dystrophy: The EEM syndrome. J Med Genet 20:52, 1983. [PubMed: 6302256] ++Senecky Y, Halpern GJ, Inbar D, et al: Ectodermal dysplasia, ectrodactyly and macular dystrophy (EEM syndrome) in siblings. Am J Med Genet 101:195, 2001. [PubMed: 11424132]