Lethal malformative syndrome characterized by
cloverleaf skull and bone dysplasia in stillborns.
Cloverleaf Skull with Generalized Bone Dysplasia.
One reported case. Male infant
stillborn at 35 weeks' gestation. Mode of genetic inheritance unknown.
Cloverleaf deformity of the skull, with extremely
broad anterior fontanel, frontal, and coronal sutures, small posterior fossa
and foramen magnum, and gross hydrocephaly. Midfacial hypoplasia
with shallow orbits, a narrow chest with long, narrow lungs, normal heart
except for a large foramen ovale with a fenestrated, diaphanous flap were further findings.
The limbs were short
with the proximal segment being most severely affected. The abdominal
contents were morphologically normal, but there were widespread petechial
hemorrhages of the organs.
Kozlowski K, Warren PS, Fisher CC: Cloverleaf skull with generalised bone
dysplasia. Report of a case with short review of the literature. Pediatr Radiol