After intrauterine growth retardation, twins
present with different physical appearance. Clinical features of the syndrome
combine short stature with microphthalmos and endocrine dysfunction
(hypothyroid, hypoglycemia, and hypothalamo-hypophysial axis anomalies).
Micropenis and ectopic testes can be associated. Mosaicism is observed in
peripheral blood, but not in skin fibroblast cultures (probably by
anastomoses between the placentae of the twins).