Progressive Supranuclear Palsy
(Steele-Richardson-Olszewski Syndrome):Progressive supranuclear palsy is
the second most frequent cause of degenerative parkinsonism. Clinical
symptoms include early postural instability and supranuclear gaze palsy.
Progressive supranuclear palsy is transmitted as an autosomal dominant
trait. This disorder begins with axial rigidity, slowness of movement, and
gait difficulty, followed by complete vertical gaze palsy, axial dystonia,
retrocollis, and severe akinesia. It is often described as a Parkinson-like
syndrome without the tremor. The term “Pick complex” has been suggested to
represent the overlapping with syndromes of frontotemporal dementia (FTD),
primary progressive aphasia, corticobasal degeneration, progressive
supranuclear palsy, and FTD with motor neuron disease.