ICE is an acronym for ichthyosis-cheek-eyebrow. Very rare
genetic disorder characterized by ichthyosis vulgaris associated with sparse
Autosomal dominant inheritance has been
Acronymic syndrome characterized by ichthyosis
vulgaris, prominent and full cheeks, and sparse lateral eyebrows. Other
features involve the head (brachycephaly, folded helix, large nose, high-arched
palate), thorax and spine (kyphoscoliosis, pes planus, pectus excavatum or carinatum,
asymmetrical rib cage with abnormally placed nipples), and limb (flat foot, genu
valgum, arachnodactyly of toes and fingers).
Cutaneous lesion could make venous
access difficult. Perimedullar blockade is not contraindicated however could
be difficult to realize because of the presence of kyphoscoliosis and skin lesions.
Careful intraoperative monitoring is needed because of skeletal deformation.
Sidransky E, Feinstein A, Goodman RM: Ichthyosis-cheek-eyebrow (ICE)
syndrome: A new autosomal dominant disorder. Clin Genet