HES is a heterogenous disease process.
Multiple clinical manifestations may occur simultaneously or individually.
Central nervous system (CNS) dysfunction (confusion, delirium, coma, dementia), congestive heart
failure, arrhythmias, pulmonary infiltrates/effusion, nonproductive cough,
hepatosplenomegaly, anemia and/or thrombocytopenia, anorexia, weight loss,
fatigue, nausea, abdominal pain, diarrhea, pruritic rash, fever, night
sweats, hepatosplenomegaly, peripheral neuritis, and venous thrombosis. Most
commonly diagnosed between 20 and 50 years of age; rare in children.