Sections View Full Chapter Figures Tables Videos Annotate Full Chapter Figures Tables Videos Supplementary Content + Download Section PDF Listen ++ See Table H-3. + Table H-3 Hereditary Motor Sensory Neuropathies (HMSN): An Overview Download Section PDF Listen ++Table Graphic Jump LocationTable H-3 Hereditary Motor Sensory Neuropathies (HMSN): An OverviewView Table||Download (.pdf)Table H-3 Hereditary Motor Sensory Neuropathies (HMSN): An OverviewTypeInheritanceEponym/SynonymCharacteristicsHMSN I (classic CMT I)Autosomal dominantCharcot-Marie-Tooth DiseaseOnset during late childhood or adolescenceVariable degree of nerve hypertrophyMyelin sheath degenerationAt least three subtypes (IA, IB, IC)HMSN I variantAutosomal dominantRoussy-Levy SyndromeCombination of HMSN type I and Friedrich's ataxiaHMSN IIAutosomal dominantCowchock SyndromeOnset usually later than type IKnown as neuronal type No nerve hypertrophy HMSN IIIAutosomal recessive Dejerine Sottas SyndromeOnset in infancy or childhood Delayed motor development Often severe nerve hypertrophy HMSN IVAutosomal recessiveRefsum SyndromeSlow motor nerve conduction velocityRetinitis pigmentosaCerebellar signs HMSN VMainly autosomal dominant (recessive forms exist)Strümpell-Lorrain DiseaseNeuropathy with spastic paraplegia with peroneal muscular atrophy and sensory loss HMSN VIMitochondrial DNA transmission (from mother only)Leber Hereditary Optic Neuropathy (LHON)Neuropathy with optic atrophyHMSN VIIOften Included in Refsum SyndromeNeuropathy with retinitis pigmentosaX-Linked HMSNX-LinkedSimilar to HMSN I but limited to malesFemales can be mildly affected HMSNLAutosomal recessiveHereditary Motor and Sensory Neuropathy-Lom TypePeripheral neuropathyTendon areflexiaSensory loss