Sections View Full Chapter Figures Tables Videos Annotate Full Chapter Figures Tables Videos Supplementary Content + At a Glance Download Section PDF Listen ++ Very rare condition characterized by corneal opacities present at birth and later-onset deafness. + Synonym Download Section PDF Listen ++ Corneal Dystrophy Perceptive Deafness. + Incidence and Genetic Inheritance Download Section PDF Listen ++ Very rare; autosomal recessive inheritance. Gene located on 20p13. + Clinical Aspects Download Section PDF Listen ++ Features involve eyes (corneal clouding or opacity, abnormal corneal structure, severe visual loss, glaucoma, buphthalmos). Sensory neural deafness also occurs but later in age. + Anesthetic Considerations Download Section PDF Listen ++ Avoid ototoxic drugs. Eye care protection is necessary because of buphthalmos. Medications that might increase eye pressure, such as atropine, succinylcholine, and ketamine, should be avoided. + References Download Section PDF Listen ++Abramowicz MJ, Albuquerque-Silva J, Zanen A: Corneal dystrophy and perceptive deafness (Harboyan syndrome): CDPD1 maps to 20p13. J Med Genet 39:110, 2002. [PubMed: 11836359] ++Harboyan G, Mamo J, Der Kaloustian VM, et al: Congenital corneal dystrophy, progressive sensorineural deafness in a family. Arch Ophthamol 85:27, 1971. [PubMed: 5312820]