Elevated partial thromboplastin time, no clinical
bleeding in normal conditions. Occasionally, mild blood loss has been
reported, mainly following trauma or surgery. Severe liver disease may lead
to reduced production of FXII, worsening the (biologic) condition. FXII
deficiency was reported to be a risk factor for thromboembolism as a result
of inactivation of fibrinolysis. The disorder may be a risk factor for early
gestational losses.