Patients present with intrauterine growth
retardation and postnatal growth delay with normal mental development. There
is decreased subcutaneous fat and thin or absent scalp hair. Main features
involve the face, which seems prematurely aged with a triangular facies,
prominent forehead, deep-set eyes, midfacial hypoplasia, prominent nasal
septum, hypoplastic alar nasae, prominent ears, and thin lips.