In all forms, coarsened facial features,
vertebral anomalies, and often bilateral macular cherry-red
spots result in progressive loss of vision. Infantile form presents with fetal hydrops,
or with death from renal and cardiac failure in infancy. Late infantile form has better
prognosis. Hepatosplenomegaly and valvular heart disease are common in this
form. The majority of patients have juvenile/adult form of
galactosialidosis. Features include spinal deformities, myoclonus, ataxia,
seizures, mental retardation, and hearing loss.