Forsius-Ericksson Syndrome

Congenital form of albinism characterized by retinal disorder with marked vision impairment and color blindness. Patients should be considered as muscular dystrophic patients unless proven otherwise.

Aland Island Eye Disease (ACE); Ocular Albinism Type II; OA II.

X-chromosome recessive ocular albinism.

Results from a mutation at Xp21.3-Xp212.2 leading to decreased dystrophin production and congenital stationary night blindness.

Ophthalmic symptoms and signs include iris transillumination, fundus hypopigmentation, congenital nystagmus, and typical electroretinogram appearance.

Aland Island eye disease is an ophthalmic diagnosis and is not associated with any other abnormalities. However, the gene locus is in close proximity to that coding for Duchenne muscular dystrophy. The coexistence of these two pathologies is well documented and should be suspected in a child with congenital night blindness who fails to reach motor milestones.

Careful history and examination should reveal symptoms and signs of coexisting pathology such as muscular dystrophy.

Patients with confirmed Aland Island eye disease should probably be treated as if they had muscular dystrophy unless there is overwhelming evidence to the contrary.

The usual pharmacological precautions for patients with Duchenne muscular dystrophy should be observed.