Drug ingestion causes fetal and early postnatal
death, but some infants survive beyond the first year. The main feature is
growth deficiency that usually has a prenatal onset and continues
postnatally. They are born with microcephaly and hypoplasia of most of the
cranial bones. Other facial feature findings are the presence of a broad
nasal bridge, shallow supraorbital ridges, prominent eyes, low-set ears,
epicanthal folds, micrognathia, and maxillary hypoplasia. Intelligence and
motor development are normal. Musculoskeletal findings are a relative
shortness of the limbs, mostly of the forearm, and talipes equinovarus.
Other occasional abnormalities, such as cleft palate, neural tube defect,
dextroposition of the heart, and hypotonia, are observed.