++
Skeletal dysplasia, broad short thumbs, and pectoral
and sternal deformities. Assess vertebral anomalies by radiologic
examination of spine. Spina bifida occulta may be present.
++
Acropectorovertebral Dysplasia; Opitz F Syndrome.
++
Autosomal dominant. Fewer than
15 cases reported in the literature.
++
Skeletal dysplasia, broad short thumbs, distal
thumb phalanx duplication, thumb and index finger syndactyly, fused capitate
and hamate, syndactyly of toes, malformed toes. Pectoral and sternal
deformities. Vertebral anomalies and spina bifida occulta at L5 or S1.
++
Assess vertebral anomalies by radiologic
examination of spine. Because spina bifida occulta may be present, there is
an increased risk of dural puncture with lumbar extradural block.
++
No specific pharmacological
implications.
++
Grosse Syndrome (Cranioacrofacial Syndrome): Autosomal dominant
condition characterized by cardiac anomalies (ventricular septal defect,
pulmonic stenosis), narrow head and face, minor head anomalies, and
Dupuytren contractures.
Grosse F, Herrmann J, Opitz JM: The F-form of acropectorovertebral
dysplasia: The F-syndrome. Birth Defects Orig Artic Ser 3:48, 1969.
Dundar M, Gordon TM, Ozyasgan I, et al: A novel acropectoral syndrome maps
to chromosome 7q36.
J Med Genet 38: 304, 2001.
[PubMed: 11333865]
Camera G, Camera A, Pozzolo S, et al: F-Syndrome (F-form of
acropectoro-vertebral dysplasia): Report on a second family.
Am J Med Genet 57:472,
1995.
[PubMed: 7677153]