Age at onset is usually between 2 and 14 years.
Patients usually present with unilateral, most often painless, asymmetrical
swelling on one side of a lower limb joint, most often the knee or ankle
(talus, tarsonavicular, or first cuneiform joints). Other anatomical sites
affected by the disease are the upper limbs, sacroiliac joint, and
acetabulum. Multiples of these chondromas may be present. Deformity of the
limb, differences in length, or a limp may be the initial symptoms. In
suspected cases, the diagnosis is confirmed by imaging studies of the
affected limb. Most often, the medial portion of the epiphysis is involved.
Treatment is surgical, but recurrence is common.