Excessive renal loss of glucose, amino acids,
potassium, bicarbonate, phosphate, calcium, water, and magnesium lead to
growth retardation/dwarfism, polyuria, polydipsia, metabolic
acidosis, muscle weakness, and rickets or osteomalacia (depending on age of onset). De
Toni Debré Fanconi syndrome can be the first manifestation of complex IV
deficiency.