Moderate-to-severe mental retardation, short
stature, mild obesity, hypogonadism (often also cryptorchidism), single
palmar crease, and a low total finger ridge count. The distinctive face is
characterized by microcephaly with bitemporal narrowness, almond-shaped
palpebral fissures, depressed nasal bridge, anteverted nares, short and
inverted V-shaped upper lip, high arched palate, and macrostomia.