Familial disorder with features limited to the eyes.
Fewer than 25 patients have been
described in the literature. Autosomal dominant.
Dysplastic malformation of the anterior segment
of the eye characterized by the combination of congenital cataract and
microcornea (diameter <11 mm). Occasionally, other ocular anomalies such as
iris coloboma, sclerocornea, myopia, or Peters anomaly (central corneal
opacity associated with abnormal corneal development that may result in
cataract, adhesions of the iris to the cornea, and glaucoma) may be present.
No known specific anesthetic problems or other
Nance-Horan Syndrome: A very rare congenital disorder combining
cataract and dental anomalies.
Green JS, Johnson GJ: Congenital cataract with microcornea and Peters'
anomaly as expressions of one autosomal dominant gene. Ophthalmic Paediatr Genet
Salmon JF, Wallis CE, Murray AD: Variable expressivity of autosomal
dominant microcornea with cataract. Arch Ophthalmol