Morphologically, patients with
pseudohyperparathyroidism type IA often present with a round face, short
stature and neck, obesity, brachydactyly with short metacarpals, mental
retardation, cataract, and delayed tooth eruption with enamel hypoplasia.
Intracranial and subcutaneous calcifications, neuromuscular problems such as
fatigue and muscle cramps, and seizures are common. Other endocrinologic
signs may include pseudohypoparathyroidism with parathyroid hyperplasia,
hypocalcemic tetany, hypothyroidism, (secondary to thyrotropin resistance),
deficient prolactin release, partial resistance to antidiuretic hormone, and
arterial hypertension. Oligomenorrhea (secondary to gonadotropin
resistance), seizures, and impaired olfaction have been described in
pseudohyperparathyroidism type IA.