The face of these mentally normal patients
usually is oval shaped with a broad nasal bridge. Partial or complete fusion
of the eyelids because of tissue bands (ankyloblepharon filiforme adnatum)
and absent lacrimal puncta may be present at birth. Eyelashes may be sparse
or absent. Photophobia and recurrent blepharoconjunctivitis are common.
Auditory canals may be atretic or stenotic, resulting in conductive hearing
loss. Ectodermal Dysplasia usually presents with sparse, coarse, wiry
scalp hair, which may progress to partial or even total alopecia, often
secondary to recurrent scalp infections. The skin appears dry and cracking
and often is hyperpigmented. Palmoplantar keratoderma is common in adults.
Dystrophic or missing nails, mild hypohidrosis, and dental anomalies such as
hypodontia, enamel defects, and abnormally shaped teeth are common findings.
Cleft lip/palate with or without maxillary hypoplasia, cupped ears,
syndactyly, hypospadias and/or micropenis, and short stature have been
reported in some patients. Cardiac defects include ventricular septal
defects and patent ductus arteriosus.