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  • Image not available. Diabetic autonomic neuropathy may limit the patient’s ability to compensate (with tachycardia and increased peripheral resistance) for intravascular volume changes and may predispose the patient to cardiovascular instability (eg, postinduction hypotension) and even sudden cardiac death.
  • Image not available. Temporomandibular joint and cervical spine mobility should be assessed preoperatively in diabetic patients to reduce the likelihood of unanticipated difficult intubation. Difficult intubation has been reported in as many as 30% of persons with type 1 diabetes.
  • Image not available. Sulfonylureas and metformin have long half-lives and many clinicians will discontinue them 24-48 h before surgery. They can be started postoperatively when the patient resumes oral intake.
  • Image not available. Incompletely treated hyperthyroid patients can be chronically hypovolemic and prone to an exaggerated hypotensive response during induction of anesthesia.
  • Image not available. Clinically hypothyroid patients are more susceptible to the hypotensive effect of anesthetic agents because of their diminished cardiac output, blunted baroreceptor reflexes, and decreased intravascular volume.
  • Image not available. Patients with glucocorticoid deficiency must receive adequate steroid replacement therapy during the perioperative period.
  • Image not available. In patients with a pheochromocytoma, drugs or techniques that indirectly stimulate or promote the release of catecholamines (eg, ephedrine, hypoventilation, or bolus doses of ketamine), potentiate the arrhythmic effects of catecholamines (classically halothane), or consistently release histamine (eg, large doses of atracurium or morphine sulfate) may precipitate hypertension and are best avoided.
  • Image not available. Obese patients may be difficult to intubate as a result of limited mobility of the temporomandibular and atlantooccipital joints, a narrowed upper airway, and a shortened distance between the mandible and sternal fat pads.
  • Image not available. The key to anesthetic management of patients with carcinoid syndrome is to avoid anesthetic and surgical techniques or agents that could cause the tumor to release vasoactive substances.

The underproduction or overproduction of hormones can have dramatic physiological and pharmacological consequences. Therefore, it is not surprising that endocrinopathies affect anesthetic management. This chapter briefly reviews normal physiology and pathophysiology of four endocrine organs: the pancreas, the thyroid, the parathyroids, and the adrenal gland. It also considers obesity and carcinoid syndrome.


Adults normally secrete approximately 50 units of insulin each day from the β cells of the islets of Langerhans in the pancreas. The rate of insulin secretion is primarily determined by the plasma glucose concentration. Insulin, the most important anabolic hormone, has multiple metabolic effects, including facilitating glucose and potassium entry into adipose and muscle cells; increasing glycogen, protein, and fatty acid synthesis; and decreasing glycogenolysis, gluconeogenesis, ketogenesis, lipolysis, and protein catabolism.

In general, insulin stimulates anabolism, whereas lack of insulin is associated with catabolism and a negative nitrogen balance (Table 34-1).

Table 34-1 Effects of Insulin.1

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