Sections View Full Chapter Figures Tables Videos Annotate Full Chapter Figures Tables Videos Supplementary Content + Classification of Different Stages of Diastolic Dysfunction Download Section PDF Listen ++ | PrintNormalImpaired RelaxationPseudonormalRestrictive FillingTMFE/A1-2<0.80.8-1.5≥2DT (ms)150-220>200150-220<160IVRT (ms)60-100>100>100<60PVFPV-S/PV-D>1>1<1<1PV-AR (cm/s)<35<35>35>35ARdur–Adur<30<30>30>30Vp>55<45<45<45E′>8 (septal)>8 (septal)<8 (septal)<8 (septal)>10 (lateral)>10 (lateral)<10 (lateral)<10 (lateral)E/E′<8 (septal)≤8 (septal)9-12>15 (septal)<8 (lateral)≤8 (lateral)(average)a>12 (lateral)a Average of septal and lateral velocities. TMF, transmitral flow; E, early filling peak velocity; A, late-filling peak velocity; DT, deceleration time of E wave; IVRT, isovolumic relaxation time; PV-S, peak velocity of systolic component; PV-D, peak velocity of diastolic component; PV-AR, peak velocity of atrial reversal flow; PV-ARdur, duration of atrial reversal flow; Adur, duration of A wave; PVF, pulmonary venous flow; E′, peak tissue velocity in early diastole; Vp, velocity of propagation. + Algorithm for Grading Diastolic Dysfunction Download Section PDF Listen ++ 1 ++ + Effect of Age on Doppler-Derived Diastolic Measurements Download Section PDF Listen ++ | PrintAge Group (years)Doppler ParameterMeasurement<2021-60a>60Transmitral lowIVRT (ms)50 ± 967-7487 ± 7E/A ratio1.9 ± 0.51.5-1.31.0 ± 0.2DT (ms)142 ± 19166-181200 ± 29A dur (ms)113 ± 17127-133138 ± 19Pulmonary vein flowS/D ratio0.8 ± 0.181.0-1.21.4 ± 0.5Ar (cm/s)16 ± 1021-2325 ± 9Ar dur (ms)66 ± 3996-112113 ± 30Lateral annulus tissue velocityE′ (cm/s)21 ± 3.820-1613 ± 3.5E′/A′ ratio3.11.9-1.50.9 ± 0.4 Values are expressed as mean ± standard deviation. aFor the age group 21-60, values are expressed as range of means. A′, late lateral annulus tissue velocity; A, late transmitral velocity; Ar, pulmonary venous atrial reversal velocity; D, pulmonary venous diastolic velocity; DT, deceleration time; dur, duration; E′, early lateral annulus tissue velocity; E, early transmitral velocity; IVRT, isovolumic relaxation time; ms, milliseconds; S, pulmonary venous systolic velocity. ++ + Reference Download Section PDF Listen ++1. Nagueh SF, Appleton CP, Gillebert TC, et al. Recommendations for the evaluation of left ventricular diastolic function by echocardiography. J Am Soc Echocardiogr. 2009;22:107-133. [PubMed: 19187853]