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Nonsteroidal anti-inflammatory drugs (NSAIDs) are anti-inflammatory, analgesic, and antipyretic agents. They are used to reduce pain, decrease stiffness, and improve function in patients with osteoarthritis (OA), rheumatoid arthritis (RA), and other forms of arthritis. They are also used for the treatment of pain including headache, dysmenorrhea, and postoperative pain.1–3 Whether their effectiveness is solely due to their anti-inflammatory or analgesic effects or other possible mechanisms is not known.4 There are at least 20 different NSAIDs currently available in the United States (Table 61-1). In addition, cyclooxygenase-2 selective inhibitors (COX-2 inhibitors, e.g., celecoxib, rofecoxib), with similar efficacy but significantly decreased gastrointestinal (GI) and platelet effects, are available.5–8

Table 61-1 Nonsteroidal Anti-Inflammatory Medications

NSAIDs are one of the most commonly used classes ...

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