Abbreviations
ABC: ATP-binding cassette
ABL: Abelson murine leukemia viral oncogene homolog
ALK: anaplastic lymphoma kinase
ALL: acute lymphoblastic leukemia
AML: acute myelocytic leukemia
APML: acute promyelocytic leukemia
ARNT: aryl hydrocarbon receptor nuclear translocator (also known as HIF-1β)
ATO: arsenic trioxide
AUC: area under the curve
BCC: basal cell carcinoma
BCL: B-cell lymphoma
BCR: breakpoint cluster region (chr22)
BCRP: breast cancer resistance protein
BH: BCL2 homology domain
BIM: BCL2-like protein 11
BRCA: breast cancer susceptibility gene
BRK: breast tumor kinase, PTK6
BTK: Bruton tyrosine kinase
CDK: cyclin-dependent kinase
CLL: chronic lymphocytic leukemia
CML: chronic myelocytic leukemia
CRL4-CRBN: cullin-RING ubiquitin ligase cereblon complex
cuSCC: cutaneous squamous cell carcinoma
CXCR4: C-X-C chemokine receptor 4
DNMT: DNA methyltransferase
ECG: electrocardiogram
EGF(R): epidermal growth factor (receptor) = HER1
EML4: echinoderm microtubule-associated protein-like 4
ER: estrogen receptor
ERK: extracellular signal-related kinase = MAPK
FGF(R): fibroblast growth factor (receptor)
FIP1L1: factor interacting with poly (A) polymerase
FKBP12: immunophilin-binding protein for tacrolimus (FK506)
FL: follicular B-cell non-Hodgkin lymphoma
FLT(1 or 4): fms-related tyrosine kinase (1 or 4) (= VEGFR1 or 3)
FMO3: flavin containing monooxygenase 3
GI: gastrointestinal
GIST: gastrointestinal stromal tumor
HDAC: histone deacetylase
HER1/2: human epidermal growth factor receptor; 1 = EGFR; 2 = erbB2
2-HG: 2-hydroxyglutarate
HGF(R): hepatocyte growth factor (receptor) = cMET
HIF-1 or -2: hypoxia-inducible factor 1 or 2
HMT: histone methyltransferase
HSC: hematopoietic stem cell
IFN: interferon
IGF1R: insulin-like growth factor 1 receptor
IκB: inhibitor of nuclear factor kappa B
IL: interleukin
IMiDs: immunomodulatory imide drugs (e.g., thalidomide)
ITK: inducible T-cell kinase
KDR: kinase insert domain receptor = VEGFR2
KIT: feline sarcoma virus oncogene homolog
LCK: lymphocyte-specific kinase
MAPK: mitogen-activated extracellular signal regulated protein kinase = ERK
MCL: mantle cell lymphoma
MCyR: major cytogenetic response
MDS: myelodysplastic syndrome
MEK: mitogen-activated extracellular signal regulated protein kinase kinase = MKK
MET: mesenchymal-epithelial transition factor (= HGFR)
MM: multiple myeloma
mTOR: mammalian or mechanistic target of rapamycin
NCCN: National Comprehensive Cancer Network
NET: neuroendocrine tumor
NF-κB: nuclear factor-κB
NK: natural killer
NPM: nucleophosmin (gene)
NRAS: neuroblastoma RAS virus homolog
NSCLC: non–small cell lung cancer
OATP: organic anion-transporting polypeptide
PARP: poly(ADP-ribose) polymerase
PDGF(R): platelet-derived growth factor (receptor)
Pgp: P-glycoprotein
PI3K: phosphatidylinositol 3-kinase
PIK3CA: PI3K catalytic subunit α gene; codes for the p110α enzyme
PIP2: phosphatidylinositol 4,5-bisphosphate
PIP3: phosphatidylinositol (3,4,5)-trisphosphate
PNET: peripheral neuroendocrine tumor
PPES: palmar-plantar erythrodysesthesia syndrome
PPI: proton pump inhibitor
PROTAC: proteolysis-targeting chimera
PTEN: phosphatase and tensin homolog
Rb: retinoblastoma (protein)
RCC: renal cell carcinoma
RET: “rearranged during transfection” receptor tyrosine kinase
ROS1: orphan receptor tyrosine kinase
SDF: stromal cell-derived factor
SLL: small lymphocytic lymphoma
TGF: transforming growth factor
TIE: tyrosine kinase with Ig and EGF domains
TKI: tyrosine kinase inhibitor
TSC: tuberous sclerosis complex
VEGF(R): vascular endothelial growth factor (receptor)
VHL: von Hippel-Lindau (pVHL = VHL protein)