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At a glance

Disorder characterized by galactorrhea and amenorrhea.

Synonyms and Classification

Amenorrhea-Galactorrhea-Hyperprolactinemia Syndrome.

  • Type I: Chiari-Frommel Syndrome: persistent AGS after giving birth.

  • Type II: Ahumada-del Castillo Syndrome (Argonz-del Castillo-Ahumada Syndrome; Amenorrhea-Galactorrhea FSH Decrease Syndrome; Nonpuerperal Galactorrhea-Amenorrhea Syndrome): AGS not associated with pregnancy. Estrogen deficiency and decreased urinary gonadotropin levels.

  • Type III: Forbes-Albright Syndrome: AGS caused by chromophobe prolactin-producing adenoma of the pituitary.

Genetic inheritance

Autosomal dominant.


Tumors resembling chromophobe adenomas of the pituitary gland with eosinophilic granulation on tetrachrome staining.

Clinical aspects

Secondary amenorrhea with galactorrhea. Enlargement of the sella turcica.

Anesthetic considerations

No known specific anesthetic considerations for this syndrome.


Rimoin  DL, Schimke  RN: Genetic Disorders of the Endocrine Glands. St. Louis, CV Mosby, 1971.

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