Acetylcysteine | Various | Acetaminophen overdose† | Cetylev29 | Effervescent tablets for oral solution | Same | Chapter 4. Drug Toxicity and Poisoning |
Aspirin and omeprazole | New fixed-dose salicylate and protein pump inhibitor combination | Yosprala30 | Delayed-release tablets | Secondary prevention of cardiovascular and cerebrovascular events in patients at risk for aspirin-associated gastric ulcers | Chapter 30. Blood, Coagulation and Anticoagulant, Fibrinolytic, and Antiplatelet Drugs; Chapter 34. Anti-inflammatory, Antipyretic and Analgesic Agents; Pharmacotherapy of Gout; Chapter 45. Pharmacotherapy of Gastric Acidity, Peptic Ulcers, and Gastroesophageal Reflux Disease |
Buprenorphine | Various | Opiate dependence | Probuphine31,32 | Intradermal implant | Same | Chapter 18. Opioids, Analgesia, and Pain |
Canagliflozin and metformin | New fixed-dose sodium-glucose co-transporter 2 (SGLT2) inhibitor and biguanide combination | Invokamet XR33 | Extended-release tablets | Type 2 diabetes mellitus | Chapter 43. Endocrine Pancreas and Pharmacotherapy Of Diabetes Mellitus and Hypoglycemia |
Carbamazepine | Various | Anticonvulsant | Carnexiv34 | IV solution† | Same | Chapter 21. Pharmacotherapy of the Epilepsies |
# and Fluocinolone | New fixed-dose fluoroquinolone and Corticosteroid combination | Otovel35 | Otic drops | Otitis media | Chapter 42. ACTH, Adrenal Steroids, and Pharmacology of the Adrenal Cortex; Chapter 52. Sulfonamides, Trimethoprim-Sulfamethoxazole, Quinolones, and Agents for Urinary Tract Infections |
Emtricitabine and rilpivirine and tenofovir alafenamide fumarate | New fixed-dose nucleoside reverse transcriptase inhibitor (NRTI) and non-nucleoside reverse transcriptase inhibitor (NNRTI) and acyclic nucleotide reverse transcriptase inhibitor combination | Odefsey36 | Tablets | HIV infection | Chapter 59. Antiretroviral Agents and Treatment of HIV Infection |
Emtricitabine and tenofovir alafenamide fumarate | New fixed-dose nucleoside reverse transcriptase inhibitor (NRTI) and acyclic nucleotide reverse transcriptase inhibitor combination | Descovy37 | Tablets | HIV infection | Chapter 59. Antiretroviral Agents and Treatment of HIV Infection |
Formoterol and glycopyrrolate | New fixed-dose long-acting beta agonist/anticholinergic combination | Bevespi38 Aerosphere | Metered-dose inhaler | COPD, emphysema, chronic bronchitis | Chapter 12. Adrenergic Agonists and Antagonists |
Granisetron | Various | Nausea/vomiting | Sustol39 | Extended-release injection | Same | Chapter 46. Treatment of Disorders of Bowel Motility and Water Flux; Anti-Emetics; Agents Used in Biliary and Pancreatic Disease |
Insulin degludec and liraglutide | New fixed-dose basal insulin/glucagon-like peptide-1 analog combination | Xultophy40 | Injection | Type 2 diabetes mellitus | Chapter 43. Endocrine Pancreas and Pharmacotherapy Of Diabetes Mellitus and Hypoglycemia |
Linagliptin and metformin | New fixed-dose dipeptidyl peptidase-4 (DPP-IV) inhibitor and biguanide combination | Jentadueto XR41 | Extended-release tablets | Type 2 diabetes mellitus | Chapter 43. Endocrine Pancreas and Pharmacotherapy Of Diabetes Mellitus and Hypoglycemia |
Nitroglycerin | Various | Angina | GoNitro42 | Powder for sublingual administration | Same | Chapter 27. Treatment of Myocardial Ischemia |
Nebivolol and valsartan | New fixed-dose beta-blocker and angiotensin II receptor blocker (ARB) combination | Byvalson43 | Tablets | Hypertension | Chapter 12. Adrenergic Agonists and Antagonists; Chapter 26. Renin and Angiotensin |
Oxycodone, extended release | Oxycontin | Severe pain | Xtampza ER44-47 | Extended-release capsules, abuse deterrent (microsphere technology) | Same | Chapter 18. Opioids, Analgesia, and Pain |
Oxycodone and naloxone (sequestered) | New fixed-dose opioid agonist opioid antagonist combination | Troxyca ER45,46,48 | Extended-release capsules, abuse deterrent (sequestered naloxone technology) | Severe pain | Chapter 18. Opioids, Analgesia, and Pain |
Oxymetazoline and tetracaine | New fixed-dose vasoconstrictor/ester local anesthetic combination | Kovanaze49 | Nasal spray | Needle-less dental anesthetic | Chapter 8. Neurotransmission: The Autonomic and Somatic Motor Nervous Systems; Chapter 20. Local Anesthetics |
Potassium, sodium, and magnesium sulfates | New fixed-dose osmotic laxative combination | ColPrep Kit50 | Powder for oral solution | Colon cleansing prior to colonoscopy | Chapter 46. Treatment of Disorders of Bowel Motility and Water Flux; Anti-Emetics; Agents Used in Biliary and Pancreatic Disease |
Riboflavin 5'-phosphate | None | Oral vitamin B2 supplementation | Photrexa5,51 | 0.146% ophthalmic solution | Keratoconus;† treatment of corneal ectasia following refractive surgery† (used in conjunction with UVA irradiation) | Chapter 37. Hematopoietic Agents: Growth Factors, Minerals, and Vitamins; Chapter 64. Ocular Pharmacology |
Photrexa Viscous5,51 | 0.146% ophthalmic solution in 20% dextran |
Tenofovirc | Tenofovir disoproxil fumaratea (Viread)52 | Hepatitis B infection, HIV infection | Vemlidy53 | Tenofovir alafenamide fumarateb | Hepatitis B infection | Chapter 58. Antiviral Agents (Nonretroviral) |