RT Book, Section A1 Gmelch, Ben A2 Johnson, Ken B. SR Print(0) ID 1103964985 T1 Anesthetic Considerations During Cardiopulmonary Bypass T2 Clinical Pharmacology for Anesthesiology YR 2015 FD 2015 PB McGraw-Hill Education PP New York, NY SN 9780071736169 LK accessanesthesiology.mhmedical.com/content.aspx?aid=1103964985 RD 2024/04/24 AB Cardiothoracic surgery entails unique, often extreme, conditions in comparison to noncardiac surgery. Profound hemodynamic and physiologic perturbations associated with hypothermic cardiopulmonary bypass (CPB) and circulatory arrest lead to unique dosing considerations for anesthetic drugs, anticoagulants, vasoactives, inotropes, and antifibrinolytics. This chapter will review the pharmacologic considerations of cardiac anesthesia chronologically in stages, from premedication and induction to pre-CPB maintenance, initiation of CPB, separation from CPB, and the post-CPB period. A special discussion will review the unique pharmacologic approach to anticipated deep hypothermic circulatory arrest (DHCA).