RT Book, Section
A1 Johnson, Ken B.
A1 Birgenheier, Nathan
A2 Johnson, Ken B.
SR Print(0)
ID 1103963540
T1 Potent Inhaled Agents
T2 Clinical Pharmacology for Anesthesiology
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071736169
LK accessanesthesiology.mhmedical.com/content.aspx?aid=1103963540
RD 2024/04/20
AB The  discovery  of  inhalation  anesthetics  has  a  colorful  history  and  began  as  early  as  the  late  1700s  with  nitrous  oxide.  One  initial  use  was  in  the  treatment  of  dental  pain  and  was  later  in  combination  with  oxygen  as  an  anesthetic.  Chloroform  was  discovered  in  1831  by  an  obstetrician,  James  Simpson,  who  used  it  to  relieve  labor  pain  for  Queen  Victoria  for  her  eighth  and  ninth  deliveries  in  the  mid-1800s.  Although  diethyl  ether  was  discovered  in  the  1600s,  it  was  not  used  as  an  anesthetic  until  the  mid-1800s  in  the  United  States,  most  notably  by  William  Morton  at  Massachusetts  General  Hospital  in  Boston,  to  successfully  anesthetize  a  patient  for  a  mandibular  tumor  resection.  In  search  of  better  anesthetics,  development  of  additional  agents  continued.  Ethyl  chloride,  an  agent  used  as  a  topical  anesthetic  to  freeze  painful  tissue,  was  later  found  to  render  patients  unconscious.  Additional  agents  developed  during  the  late  1800s  were  ethylene  and  cyclopropane,  and  during  the  early  1900s,  divinyl  ether  was  developed.