RT Book, Section
A1 Bissonnette, Bruno
A1 Luginbuehl, Igor
A1 Marciniak, Bruno
A1 Dalens, Bernard J.
SR Print(0)
ID 58084033
T1 Protein C Deficiency
T2 Syndromes: Rapid Recognition and Perioperative Implications
YR 2006
FD 2006
PB The McGraw-Hill Companies
PP New York, NY
SN 9780071354554
LK accessanesthesiology.mhmedical.com/content.aspx?aid=58084033
RD 2024/04/19
AB Congenital  or  acquired  control  of  the  clotting  mechanism  resulting  in  a  widespread  thrombotic  tendency.  Protein  C  is  a  vitamin  K-dependent  serine  protease  zymogen  that  selectively  inhibits  factors  Va  and  VIII:C  in  human  plasma,  and  thus  has  an  important  anticoagulant  role.  It  is  associated  with  an  increased  tendency  to  thrombosis.  It  is  either  inherited  or  acquired:  bacterial  sepsis  (especially  of  meningococcal  origin),  hepatic  disease,  disseminated  intravascular  coagulation,  l-asparaginase  therapy,  nephrotic  syndrome,  conditioning  therapy  in  bone  marrow  transplantation,  warfarin-induced  skin  lesions.