RT Book, Section A1 Rodriguez-Roisin, Roberto A1 Ferrer, Antoni A2 Tobin, Martin J. SR Print(0) ID 57072430 T1 Chapter 37. Effect of Mechanical Ventilation on Gas Exchange T2 Principles and Practice of Mechanical Ventilation, 3e YR 2013 FD 2013 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-173626-8 LK accessanesthesiology.mhmedical.com/content.aspx?aid=57072430 RD 2024/04/24 AB The major function of the lung is to exchange physiologic (respiratory) gases, namely oxygen (O2) and carbon dioxide (CO2). Once the lungs fail as a gas exchanger, arterial hypoxemia, hypercapnia, or both appear and respiratory failure ensues. Arterial PO2 (PaO2) and () are the measurable end-point variables used routinely by clinicians to manage patients with acute respiratory failure. When the latter is severe, mechanical ventilation is then considered the final strategy for treating patients.