RT Book, Section
A1 Butterworth, John
A2 Hadzic, Admir
SR Print(0)
ID 3498691
T1 Chapter 6. Clinical Pharmacology of Local Anesthetics
T2 NYSORA Textbook of Regional Anesthesia and Acute Pain Management
YR 2007
FD 2007
PB The McGraw-Hill Companies
PP New York, NY
SN 9780071449069
LK accessanesthesiology.mhmedical.com/content.aspx?aid=3498691
RD 2024/04/19
AB Local  and  regional  anesthesia,  defined  as  the  selective  numbing  of  a  specific  nerve  distribution  or  region  of  the  body  to  facilitate  surgery,  appear  to  be  undergoing  a  renaissance,  as  judged  by  attendance  at  specialty  meetings  and  numbers  of  published  manuscripts.  In  contrast  to  general  anesthesia,  in  which  the  molecular  mechanism  remains  the  subject  of  speculation,  the  site  at  which  local  anesthetic  drugs  bind  to  produce  nerve  blocks  has  been  cloned  and  mutated.  This  chapter  will  focus  on  mechanisms  of  anesthesia  and  toxicity,  especially  as  knowledge  of  these  mechanisms  will  assist  the  clinician  in  conducting  safer  and  more  effective  regional  anesthetics.