RT Book, Section A1 Sala-Blanch, Xavier A1 de Andrés, Jose A A1 Dewaele, Steven A2 Hadzic, Admir SR Print(0) ID 1141736477 T1 Acute Compartment Syndrome of the Limb: Implications for Regional Anesthesia T2 Hadzic's Textbook of Regional Anesthesia and Acute Pain Management, 2e YR 2017 FD 2017 PB McGraw-Hill Education PP New York, NY SN 9780071717595 LK accessanesthesiology.mhmedical.com/content.aspx?aid=1141736477 RD 2024/04/19 AB Compartment syndrome is an orthopedic emergency. It is an acute condition of the limbs in which the pressure of isolated or groups of poorly compliant muscle compartments increases dramatically and limits local soft tissue perfusion to the point of motor and sensory impairment and neuronal and tissue ischemic necrosis. Although regional anesthesia is often thought to delay diagnosis and treatment of acute compartment syndrome (ACS), there are only isolated case reports and a lack of evidence-based information to guide the clinical practice. Regardless, practitioners should be aware of the patient risk factors, clinical presentation, and management of this potentially limb-threatening condition. The musculoskeletal structures of the limbs are enclosed within compartments created by investing fascial layers with a limited ability to stretch. These compartments enclose skeletal muscles along with the neurovascular structures that pass through the compartments. If missed, compartment syndrome1 can be a limb- and life-threatening condition.