RT Book, Section A1 Sherman, Caitlin A1 Gauthier, Mandeep A1 David, Marianne A2 Freeman, Brian S. A2 Berger, Jeffrey S. SR Print(0) ID 1135743203 T1 Supine Hypotensive Syndrome of Pregnancy T2 Anesthesiology Core Review: Part Two Advanced Exam YR 2016 FD 2016 PB McGraw-Hill Education PP New York, NY SN 9781259641770 LK accessanesthesiology.mhmedical.com/content.aspx?aid=1135743203 RD 2024/04/25 AB Although cardiac output increases by 30%–40%, blood pressure is normally lower during pregnancy due to a 15% decrease in systemic vascular resistance. Furthermore, in the supine position, venous return decreases and cardiac output can be significantly affected with a drop of 25%–30% in the latter half of pregnancy (>20 weeks) when aortocaval compression is at its greatest. This compression of the aorta and the inferior vena cava against the lumbar vertebral bodies results in decreased venous return from the lower extremities, thereby decreasing preload, stroke volume and cardiac output.